One Polypeptide in Insulin?

Multiple genes, one polypeptide chain.

Insulin--the natural polypeptide for diabetes management.

Insulin is a remarkably effective polypeptide that is most potent & natural therapy of pancreatic diabetes mellitus. No less than fi ve noble laureates owe their glory to this molecule. However, it is one of the most underused medical therapies of mankind. Unfortunately it is poorly prescribed by so many physicians who treat diabetes and so unsuccessfully used by so many individuals who have di...

Islet amyloid polypeptide inhibits insulin secretion in conscious rats.

To investigate the effect of islet amyloid polypeptide (IAPP, amylin) exposure on insulin secretion in vivo, the plasma glucose level of conscious rats was clamped at 11.1 mmol/l (hyperglycemic clamp) during the last 2 h of a 24-h infusion study. Group parameters were A, 24-h saline; B and C, 22-h saline followed by 2-h IAPP (B, 8.5 pmol/min; C, 85 pmol/min), and D, 24-h IAPP (85 pmol/min). Ind...

EVALU ATION OF INSULIN-SUL FONYLUREA COMBINATION V ERSIJS INSULIN AL ONE IN THE T REATMENT OF NON-INSULIN D EPENDENT DIABETES MELLITU S (NID DM)

Lowering the glucose level in diabetic patients reduces the risk of many consequences which are usually reported in these patients. Non-insulin dependent (type II) diabetes which cannot be controlled with sulfonylureas alone can be controlled with a combination of sulfonylurea and insulin. In an open randomized trial 58 patients were divided into three groups. The fIrst group received only ...

One-step preparation of the polypeptide chains of -crystallin.